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Overview

ASUS ESC4000A-E12: High-Density 2U 1-Socket Accelerator Server

Supercharge your enterprise AI and high-performance computing (HPC) with the ASUS ESC4000A-E12. This powerful 2U single-socket server is engineered to maximize ROI, driven by AMD EPYC™ 9005 / 9004 series processors with AMD 3D V-Cache™ technology. Designed for extreme graphical and computational acceleration, it supports up to four dual-slot GPUs (or eight single-slot GPUs), delivering immense parallel processing power.

Optimized Single-Socket GPU Acceleration

The ASUS ESC4000A-E12 is a purpose-built 2U accelerator server designed to meet the extreme demands of modern AI and data analytics. Powered by a single AMD EPYC™ 9005 or 9004 series processor with AMD 3D V-Cache™ technology, it supports up to 96 cores and a TDP of up to 400 watts. This highly optimized 1-socket architecture delivers the compute performance typically expected from dual-socket systems, drastically reducing total cost of ownership (TCO) and software licensing fees.

Massive GPU Capacity for AI & HPC

Built for parallel processing, this server is an AI and HPC powerhouse. It supports up to four dual-slot active or passive GPUs or up to eight single-slot GPUs, making it highly adaptable to your specific accelerator needs. With support for the NVIDIA NVLink® bridge and NVIDIA Bluefield DPU, the ESC4000A-E12 enables seamless performance scaling, ensuring massive datasets and complex deep learning models are processed with ultra-low latency.

Industry-Leading Memory & Gen5 Bandwidth

Feed your accelerators without bottlenecks. The system features 12 DDR5 DIMM slots (12-channel, 1 DIMM per channel) supporting up to 3TB of memory capacity at speeds up to 4800 MHz. Furthermore, it is fully PCIe Gen5.0 Ready, delivering 64 GT/s bandwidth—twice the speed of PCIe 4.0. With up to 12 total PCIe expansion slots, you have unparalleled lane scalability for high-speed NICs, extra storage, and compute cards.

Flexible Hybrid Storage & Enterprise Management

The front panel offers a highly versatile hybrid storage configuration featuring six hot-swap bays (two 2.5" and four 3.5"). Depending on the SKU, it supports a mix of NVMe, SATA, and SAS drives, providing the perfect balance between high-speed caching and bulk data capacity. For IT administrators, the server includes the ASUS ASMB11-iKVM remote control module, ASUS Control Center software, and a hardware-level Root-of-Trust solution for secure, comprehensive out-of-band management.

Ideal Target Applications:

Enterprise AI & HPC: Support for four dual-slot GPUs accelerates deep learning, machine learning, and scientific simulations.
Virtualized & VDI Applications: High core counts and 3TB memory capacity allow for dense, responsive virtual desktop deployments.
Cloud Computing: An economic 1-socket design maximizes cloud service profitability and performance per watt.
Streaming Media: Leverage high PCIe 5.0 bandwidth and dense storage for rapid content delivery and rendering.

Characteristics

Processor 1 x Socket SP5 (LGA 6096) AMD EPYC 9005/9004 series (up to 400W) 4th Generation AMD EPYC Processors with AMD 3D V-Cache technology

Memory Total Slots 12 (12-channel per CPU, 1 DIMM per CPU)

Memory Capacity Maximum up to 3TB per CPU socket

Memory Type DDR5 4800/4400 RDIMM/3DS RDIMM

Memory Sizes 64GB, 32GB, 16GB RDIMM / 256GB, 128GB 3DS RDIMM

Expansion Slots 12 Total PCI/PCI-E/PIKE Slots

Expansion Slots - Rear (GPU Focus) 4 x PCIe x16 slots (Gen5 x16 link, FH, FL) for dual-slot GPU cards OR 8 x PCIe x16 slots (Gen5 x8 link, FH, FL) for single-slot GPU cards

Expansion Slots - Rear (Networking/HBA) 1 x PCIe x16 slot (Gen5 x16 link, FH, HL) 1 x PCIe x16 slot (Gen5 x16/x8 link, FH, HL) or OCP socket option 1 x PCIe x8 slot (Gen5 x0/x8 link, LP, HL)

Expansion Slots - Front 1 x PCIe x8 slot (Gen5 x8 link, LP, HL) Only for SKU1

Drive Bays 6 total (2 x 2.5" & 4 x 3.5" Hot-swap Storage Bays)

SKU1 Configuration 2 x 2.5" SATA/SAS/NVMe + 2 x 3.5" SATA/SAS/NVMe + 2 x 3.5" SATA/SAS

SKU2 Configuration 2 x 2.5" SATA/SAS/NVMe + 4 x 3.5" SATA/SAS/NVMe (Occupies 1 x PCIe x8 link)

Storage Controllers 6 x SATA 6Gb/s ports natively. SAS support requires optional ASUS PIKE II or Broadcom MegaRAID HBA/RAID cards

LAN 2 x Gigabit LAN ports (Intel I350 Controller) + 1 x Management Port

Graphic Aspeed AST2600 64MB (VGA)

Front I/O Ports 4 x USB 3.2 Gen1 ports

Rear I/O Ports 2 x USB 3.2 Gen1 ports, 2 x Gigabit LAN ports (RJ45), 1 x Management port (RJ45), 1 x VGA port

Front Switch/LED 1 x Power Button/LED, 1 x Location Button/LED, 1 x Message LED, 1 x Q-Code/Port 80 LED, 2 x LAN LED

Rear Switch/LED 1 x Power Button/LED, 1 x Location LED, 1 x Message LED

Software ASUS Control Center (Classic)

Out of Band Remote Management On-Board ASMB11-iKVM

Power Supply 1+1 Redundant 2600W 80 PLUS Titanium CRPS-R Power Supply

Form Factor 2U Rackmount

Dimension 800mm x 439.5mm x 88.9mm (2U) / 845.45mm x 439.5mm x 88.9mm (2U) for immersion cooling

Net Weight 24 kg (CPU, DRAM & HDD not included)

Overview

ASUS ESC4000A-E12: High-Density 2U 1-Socket Accelerator Server

Supercharge your enterprise AI and high-performance computing (HPC) with the ASUS ESC4000A-E12. This powerful 2U single-socket server is engineered to maximize ROI, driven by AMD EPYC™ 9005 / 9004 series processors with AMD 3D V-Cache™ technology. Designed for extreme graphical and computational acceleration, it supports up to four dual-slot GPUs (or eight single-slot GPUs), delivering immense parallel processing power.

Optimized Single-Socket GPU Acceleration

The ASUS ESC4000A-E12 is a purpose-built 2U accelerator server designed to meet the extreme demands of modern AI and data analytics. Powered by a single AMD EPYC™ 9005 or 9004 series processor with AMD 3D V-Cache™ technology, it supports up to 96 cores and a TDP of up to 400 watts. This highly optimized 1-socket architecture delivers the compute performance typically expected from dual-socket systems, drastically reducing total cost of ownership (TCO) and software licensing fees.

Massive GPU Capacity for AI & HPC

Built for parallel processing, this server is an AI and HPC powerhouse. It supports up to four dual-slot active or passive GPUs or up to eight single-slot GPUs, making it highly adaptable to your specific accelerator needs. With support for the NVIDIA NVLink® bridge and NVIDIA Bluefield DPU, the ESC4000A-E12 enables seamless performance scaling, ensuring massive datasets and complex deep learning models are processed with ultra-low latency.

Industry-Leading Memory & Gen5 Bandwidth

Feed your accelerators without bottlenecks. The system features 12 DDR5 DIMM slots (12-channel, 1 DIMM per channel) supporting up to 3TB of memory capacity at speeds up to 4800 MHz. Furthermore, it is fully PCIe Gen5.0 Ready, delivering 64 GT/s bandwidth—twice the speed of PCIe 4.0. With up to 12 total PCIe expansion slots, you have unparalleled lane scalability for high-speed NICs, extra storage, and compute cards.

Flexible Hybrid Storage & Enterprise Management

The front panel offers a highly versatile hybrid storage configuration featuring six hot-swap bays (two 2.5" and four 3.5"). Depending on the SKU, it supports a mix of NVMe, SATA, and SAS drives, providing the perfect balance between high-speed caching and bulk data capacity. For IT administrators, the server includes the ASUS ASMB11-iKVM remote control module, ASUS Control Center software, and a hardware-level Root-of-Trust solution for secure, comprehensive out-of-band management.

Ideal Target Applications:

Enterprise AI & HPC: Support for four dual-slot GPUs accelerates deep learning, machine learning, and scientific simulations.
Virtualized & VDI Applications: High core counts and 3TB memory capacity allow for dense, responsive virtual desktop deployments.
Cloud Computing: An economic 1-socket design maximizes cloud service profitability and performance per watt.
Streaming Media: Leverage high PCIe 5.0 bandwidth and dense storage for rapid content delivery and rendering.